Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
St Pourcain B, Skuse DH, Mandy WP et al.
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Abstract
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Social-communication abilities are heritable traits, and their impairments overlap with the autism continuum. To characterise the genetic architecture of social-communication difficulties developmentally and identify genetic links with the autistic dimension, we conducted a genome-wide screen of social-communication problems at multiple time-points during childhood and adolescence.
Up to 5,628 European ancestry individuals
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