A study of genetic variants associated with skin traits in the Vietnamese population
Nguyen Thi Mai, Le Van Duc, Pham Minh Khuong et al.
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Abstract
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Skin pigmentation is a complex trait influenced by genetic variants, environmental factors, and their interactions. While genome-wide association studies (GWAS) have identified numerous loci associated with skin pigmentation in European populations, the genetic architecture of skin traits in Southeast Asian populations remains understudied. Here, we conducted a comprehensive genetic analysis of skin-related traits in 1,858 Vietnamese individuals. We performed GWAS for skin pigmentation, sun sensitivity, and tanning response using genome-wide SNP data. Our analysis identified several novel loci associated with skin traits in the Vietnamese population, including variants in genes previously unreported in skin pigmentation studies. We found that some European-associated variants showed different effect sizes or directions in Vietnamese individuals, highlighting population-specific genetic architectures. Additionally, we identified ancestry-informative markers that correlate with skin pigmentation variation within Vietnam. Our findings contribute to understanding the genetic basis of skin traits in Southeast Asian populations and emphasize the importance of including diverse populations in genetic studies.
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