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GWAS Study

Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.

Malhotra AK, Correll CU, Chowdhury NI et al.

22566560 PubMed ID
GWAS Study Type
344 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MA
Malhotra AK
CC
Correll CU
CN
Chowdhury NI
MD
Müller DJ
GP
Gregersen PK
LA
Lee AT
TA
Tiwari AK
KJ
Kane JM
FW
Fleischhacker WW
KR
Kahn RS
OR
Ophoff RA
MH
Meltzer HY
LT
Lencz T
KJ
Kennedy JL
Chapter II

Abstract

Summary of the research findings

Context: Second-generation antipsychotics (SGAs) are increasingly used in the treatment of many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk.

77 European ancestry individuals, 32 African American individuals, 30 individuals

Chapter III

Study Statistics

Key metrics and study information

344
Total Participants
GWAS
Study Type
Yes
Replicated
183 European ancestry individuals, 22 African American individuals
Replication Participants
African American or Afro-Caribbean, European
Ancestry
U.S., Germany
Recruitment Country
Chapter IV

AI-Generated Summary

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