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GWAS Study

Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.

Herrera-Luis E, Espuela-Ortiz A, Lorenzo-Diaz F et al.

32841424 PubMed ID
GWAS Study Type
4353 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HE
Herrera-Luis E
EA
Espuela-Ortiz A
LF
Lorenzo-Diaz F
KK
Keys KL
MA
Mak ACY
EC
Eng C
HS
Huntsman S
VJ
Villar J
RJ
Rodriguez-Santana JR
BE
Burchard EG
PM
Pino-Yanes M
Chapter II

Abstract

Summary of the research findings

Severe asthma exacerbations are a major cause of asthma morbidity and increased healthcare costs. Several studies have shown racial and ethnic differences in asthma exacerbation rates. We aimed to identify genetic variants associated with severe exacerbations in two high-risk populations for asthma.

1,283 Latino cases, 2,027 Latino controls

Chapter III

Study Statistics

Key metrics and study information

4353
Total Participants
GWAS
Study Type
Yes
Replicated
448 African American cases, 595 African American controls
Replication Participants
Hispanic or Latin American, African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

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