Multi-ancestry genome-wide association study of asthma exacerbations.
Herrera-Luis E, Ortega VE, Ampleford EJ et al.
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Abstract
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Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. We aimed to identify common genetic loci associated with asthma exacerbations across diverse populations and to assess their functional role in regulating DNA methylation and gene expression.
1,007 European ancestry cases, 3,982 European ancestry controls, 43 East Asian ancestry cases, 1,207 East Asian ancestry controls, 1,283 Hispanic or Latin American cases, 898 Hispanic or Latin American controls, 448 African American cases, 524 African American controls
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