Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.
Dong J, Maj C, Tsavachidis S et al.
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Abstract
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Background & aims: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain largely unexplored.
6,758 European ancestry male cases, 1,670 European ancestry female cases, 7,489 European ancestry male controls, 6,174 European ancestry female controls
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