Proteome-wide Mendelian randomization identifies causal links between blood proteins and acute pancreatitis.
Bourgault J, Abner E, Manikpurage HD et al.
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Abstract
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Background & aims: Acute pancreatitis (AP) is a complex disease and the leading cause of gastrointestinal disease-related hospital admissions. Few therapeutic options exist for AP prevention. Blood proteins with causal evidence may represent promising drug targets, but few have been causally linked with AP. Our objective was to identify blood proteins linked with AP by combining genome-wide association meta-analysis and proteome-wide Mendelian randomization (MR) studies.
10,630 European ancestry cases, 844,679 European ancestry controls
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