Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS.
Andlauer TFM, Link J, Martin D et al.
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Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated with different interferon β preparations.
392 German and Swedish ancestry cases, 753 German and Swedish ancestry controls
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