IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
Zhang Z, Trypsteen W, Blaauw M et al.
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Abstract
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Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 replication after treatment interruption. These HIV-1 reservoirs mainly comprise long-lived resting memory CD4+ T cells and are established early after infection. There is a high variation in the size of these viral reservoirs among virally suppressed individuals. Identification of host factors that contribute to or can explain this observed variation could open avenues for new HIV-1 treatment strategies.
207 Dutch ancestry individuals
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