Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.
Bowden SJ, Bodinier B, Kalliala I et al.
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Abstract
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Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to compare genetic variation in women with invasive cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 with that in healthy controls.
4,005 European ancestry cases, 145,545 European ancestry controls
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