Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia.
Tideman JWL, Pärssinen O, Haarman AEG et al.
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Abstract
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Importance: Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and hyperopia. Addressing this question is fundamental to understanding the genetics of refractive error and has clinical relevance for genotype-based prediction of children at risk for HM and for identification of new therapeutic targets.
11,197 European ancestry low myopic cases, 21,416 European ancestry emmetropia controls
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