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GWAS Study

Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Hu Y, Bien SA, Nishimura KK et al.

34107879 PubMed ID
GWAS Study Type
27236 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HY
Hu Y
BS
Bien SA
NK
Nishimura KK
HJ
Haessler J
HC
Hodonsky CJ
BA
Baldassari AR
HH
Highland HM
WZ
Wang Z
PM
Preuss M
SC
Sitlani CM
WG
Wojcik GL
TR
Tao R
GM
Graff M
HL
Huckins LM
SQ
Sun Q
CM
Chen MH
MA
Mousas A
AP
Auer PL
LG
Lettre G
TW
Tang W
QL
Qi L
TB
Thyagarajan B
BS
Buyske S
FM
Fornage M
HL
Hindorff LA
LY
Li Y
LD
Lin D
RA
Reiner AP
NK
North KE
LR
Loos RJF
RL
Raffield LM
PU
Peters U
AC
Avery CL
KC
Kooperberg C
Chapter II

Abstract

Summary of the research findings

Circulating white blood cell and platelet traits are clinically linked to various disease outcomes and differ across individuals and ancestry groups. Genetic factors play an important role in determining these traits and many loci have been identified. However, most of these findings were identified in populations of European ancestry (EA), with African Americans (AA), Hispanics/Latinos (HL), and other races/ethnicities being severely underrepresented.

27,236 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

27236
Total Participants
GWAS
Study Type
Yes
Replicated
728,194 European ancestry, East Asian ancestry, African American or Afro-Caribbean, Hispanic or Latin American, South Asian ancestry individuals
Replication Participants
European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian, African American or Afro-Caribbean, Hispanic or Latin American, South Asian
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.