Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function.
Monteiro-Martins S, Li Y, Borisov O et al.
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Abstract
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Introduction: Chronic kidney disease (CKD) is defined as sustained abnormalities in kidney function or structure. Genetic studies of CKD have largely focused on kidney function markers such as estimated glomerular filtration rate (eGFR). We hypothesized that genome-wide association studies (GWAS) of magnetic resonance imaging (MRI)-based kidney sub-volumes could provide insights into CKD risk genes complementary to the study of eGFR.
38,816 European ancestry individuals
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