Menu
GWAS Study

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

Perera MA, Cavallari LH, Limdi NA et al.

23755828 PubMed ID
GWAS Study Type
965 Participants
Scroll to explore
Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PM
Perera MA
CL
Cavallari LH
LN
Limdi NA
GE
Gamazon ER
KA
Konkashbaev A
DR
Daneshjou R
PA
Pluzhnikov A
CD
Crawford DC
WJ
Wang J
LN
Liu N
TN
Tatonetti N
BS
Bourgeois S
TH
Takahashi H
BY
Bradford Y
BB
Burkley BM
DR
Desnick RJ
HJ
Halperin JL
KS
Khalifa SI
LT
Langaee TY
LS
Lubitz SA
NE
Nutescu EA
OM
Oetjens M
SM
Shahin MH
PS
Patel SR
SH
Sagreiya H
TM
Tector M
WK
Weck KE
RM
Rieder MJ
SS
Scott SA
WA
Wu AH
BJ
Burmester JK
WM
Wadelius M
DP
Deloukas P
WM
Wagner MJ
MT
Mushiroda T
KM
Kubo M
RD
Roden DM
CN
Cox NJ
AR
Altman RB
KT
Klein TE
NY
Nakamura Y
JJ
Johnson JA
Chapter II

Abstract

Summary of the research findings

VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans.

533 African American individuals

Chapter III

Study Statistics

Key metrics and study information

965
Total Participants
GWAS
Study Type
Yes
Replicated
432 African American individuals
Replication Participants
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.