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GWAS Study

Genome-wide association study of warfarin maintenance dose in a Brazilian sample.

Parra EJ, Botton MR, Perini JA et al.

26265036 PubMed ID
GWAS Study Type
2967 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PE
Parra EJ
BM
Botton MR
PJ
Perini JA
KS
Krithika S
BS
Bourgeois S
JT
Johnson TA
TT
Tsunoda T
PM
Pirmohamed M
WM
Wadelius M
LN
Limdi NA
CL
Cavallari LH
BJ
Burmester JK
RA
Rettie AE
KT
Klein TE
JJ
Johnson JA
HM
Hutz MH
SG
Suarez-Kurtz G
Chapter II

Abstract

Summary of the research findings

Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians.

180 Brazilian ancestry low dose individuals, 187 Brazilian ancestry high dose individuals

Chapter III

Study Statistics

Key metrics and study information

2967
Total Participants
GWAS
Study Type
Yes
Replicated
798 European ancestry individuals, 1611 Japanese ancestry individuals, 191 African American individuals
Replication Participants
European, East Asian, Hispanic or Latin American, African American or Afro-Caribbean
Ancestry
Brazil
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.