The obesity-risk variant of FTO is inversely related with the So-Eum constitutional type: genome-wide association and replication analyses.
Cha S, Yu H, Park AY et al.
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Abstract
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Body constitutional types described in the traditional Korean medicine system, Sasang constitutional medicine, are heritable, as has been revealed by twin and family studies. Thus, individuals with the same constitution type usually have similar pathophysiological and psychological traits. In several recent genome-wide association (GWA) analyses performed to identify constitution-associated variants, the association signals were not replicated due to small sample size and dissimilar, non-objective methods for classification of the constitutional types.
1,905 Korean ancestry So-Eum type individuals, 1,905 Korean ancestry non-So-Eum type individuals
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