An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Jiang X, Källberg H, Chen Z et al.
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Abstract
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Objective: To investigate the gene-environment interaction between smoking and single nucleotide polymorphisms (SNPs), using Immunochip material, on the risk of developing either of two serologically defined subsets of RA.
340 European ancestry never-smoker cases, 493 European ancestry ever-smoker cases, 746 European ancestry never-smoker controls, 994 European ancestry ever-smoker controls
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