Pyrexia in dabrafenib-treated melanoma patients is not associated with common genetic variation or HLA polymorphisms.
Kulkarni D, Song K, Briley L et al.
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Aim: Pyrexia is a common adverse event (AE) on dabrafenib treatment (monotherapy or combination with trametinib). Since germline SNPs and HLA alleles are implicated in drug-induced AEs, this study investigated their association with pyrexia.
218 European ancestry cases with pyrexia, 361 European ancestry exposed cases without pyrexia
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