Association of germline genetic variants with <i>TMPRSS2-ERG</i> fusion status in prostate cancer.
Kohaar I, Li Q, Chen Y et al.
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Abstract
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Introduction: Oncogenic activation of ERG resulting from TMPRSS2-ERG gene fusion is a key molecular genetic alteration in prostate cancer (CaP). The frequency of ERG fusion is variable by race; however, there are limited data available on germline polymorphisms associating with ERG fusion status. The goal of this study is to identify the inherited risk variants associating with ERG status of CaP.
216 African American cases, 105 European ancestry cases
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