PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.
Pagadala MS, Linscott JA, Talwar JV et al.
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Abstract
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Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk score (PRS) models are based on European ancestry groups and may not be broadly applicable. The objective of this study was to construct an African ancestry-specific PrCa PRS (PRState) and evaluate its performance.
4,533 African ancestry individuals
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