Genomewide Association Study of Acute Anterior Uveitis Identifies New Susceptibility Loci.
Huang XF, Li Z, De Guzman E et al.
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Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are strongly associated with human leukocyte antigen (HLA)-B27, implying a shared etiology. This study aims to apply genomewide association study (GWAS) to characterize the genetic associations of AAU and their relationship to the genetics of AS.
2,752 European ancestry cases, 3,836 European ancestry controls
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