Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.
Kamimura S, Tamura A, Ishii T et al.
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Background/aim: Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach.
195 Japanese ancestry cases, 1,553 Japanese ancestry controls
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