Genetic variants that associate with liver cirrhosis have pleiotropic effects on human traits.
Chen VL, Chen Y, Du X et al.
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Background and aims: Cirrhosis is characterized by extensive fibrosis of the liver and is a major cause of liver-related mortality. Cirrhosis is partially heritable but genetic contributions to cirrhosis have not been systemically explored. Here, we carry out association analyses with cirrhosis in two large biobanks and determine the effects of cirrhosis associated variants on multiple human disease/traits.
1,088 British ancestry cases, 407,873 British ancestry controls
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