Shared genetic influences on depression and menopause symptoms.
Meijsen JJ, Shen H, Vemuri M et al.
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Abstract
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Women experience major depression and post-traumatic stress disorder (PTSD) approximately twice as often as men. Estrogen is thought to contribute to sex differences in these disorders, and reduced estrogen is also known to be a key driver of menopause symptoms such as hot flashes. Moreover, estrogen is used to treat menopause symptoms. In order to test for potential shared genetic influences between menopause symptoms and psychiatric disorders, we conducted a genome-wide association study (GWAS) of estrogen medication use (as a proxy for menopause symptoms) in the UK Biobank.
up to 10,103 European ancestry cases, up to 222,890 European ancestry controls
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