Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study.
Edris A, Voorhies K, Lutz SM et al.
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Abstract
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Asthma exacerbations reflect disease severity, affect morbidity and mortality, and may lead to declining lung function. Inflammatory endotypes (e.g. T2-high (eosinophilic)) may play a key role in asthma exacerbations. We aimed to assess whether genetic susceptibility underlies asthma exacerbation risk and additionally tested for an interaction between genetic variants and eosinophilia on exacerbation risk.
11,604 European ancestry cases, 37,890 European ancestry controls
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