Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.
Gong W, Guo P, Li Y et al.
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Abstract
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Importance: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) hypothesized as a potential biological basis. However, the degree to which the shared genetic determinants are involved in these associations underlying the GBA is unclear.
7,045 European ancestry inflammatory bowel disease cases, 170,056 European ancestry major depressive disorder cases, 778,725 European ancestry controls
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