A high-coverage genome sequence from an archaic Denisovan individual
Meyer M, Kircher M, Gansauge MT et al.
Publication Details
Comprehensive information about this research publication
Abstract
Summary of the research findings
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
Ancient DNA Samples
33 ancient DNA samples referenced in this publication
| Sample ID | Date/Era | Country | Locality | Sex | mtDNA | Y-DNA |
|---|---|---|---|---|---|---|
| HGDP00998 | 0 | Brazil | M | |
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| HGDP00998 | 2000 CE | Brazil | M | |
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| HGDP00998 | 2000 CE | Brazil | M | |
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| HGDP00778 | 0 | China | M | |
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| HGDP01307 | 0 | China | M | |
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| HGDP01307 | 2000 CE | China | M | |
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| HGDP00778 | 2000 CE | China | M | |
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| HGDP01307 | 2000 CE | China | M | |
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| HGDP00778 | 2000 CE | China | M | |
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| HGDP00456 | 0 | Congo | M | |
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| HGDP00456 | 2000 CE | Congo | M | |
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| HGDP00456 | 2000 CE | Congo | M | |
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| HGDP00521 | 0 | France | M | |
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| HGDP00521 | 2000 CE | France | M | |
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| HGDP00521 | 2000 CE | France | M | |
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| HGDP00665 | 0 | Italy | Sardinia | M | |
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| HGDP00665 | 2000 CE | Italy | Sardinia | M | |
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| HGDP00665 | 2000 CE | Italy | M | |
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| HGDP01029 | 0 | Namibia | M | |
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| HGDP01029 | 2000 CE | Namibia | M | |
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| HGDP01029 | 2000 CE | Namibia | M | |
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| HGDP00927 | 0 | Nigeria | M | |
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| HGDP00927 | 2000 CE | Nigeria | M | |
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| HGDP00927 | 2000 CE | Nigeria | M | |
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| HGDP00551 | 0 | Papua New Guinea | M | |
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| HGDP00551 | 2000 CE | Papua New Guinea | M | |
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| HGDP00551 | 2000 CE | Papua New Guinea | New Guinea. Iatmul and Kwoma societies of the Middle Sepik River region | M | |
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| Denisova | 74250 BCE | Russia | Denisova Cave. Altai | F | DN1a1 |
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| Denisova | 74250 BCE | Russia | Denisova Cave. Altai | F | DN1a1 |
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| HGDP01284 | 0 | Senegal | M | |
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| HGDP01284 | 2000 CE | Senegal | M | |
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| HGDP01284 | 2000 CE | Senegal | M | |
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| A_Dinka-4 | 2000 CE | South Sudan | Aweil | M | |
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Analysis
Comprehensive review of ancestry and genetic findings
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