Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
Stefansson H, Steinberg S, Petursson H et al.
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Abstract
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We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]
452 European ancestry cases, 14,378 European ancestry controls
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