Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.
Knauff EA, Franke L, van Es MA et al.
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Spontaneous premature ovarian failure (POF) occurs in 1% of women and has major implications for their fertility and health. Besides X chromosomal aberrations and fragile X premutations, no common genetic risk factor has so far been discovered in POF. Using high-density single nucleotide polymorphism (SNP) arrays, we set out to identify new genetic variants involved in this condition.
99 European ancestry cases, 235 European ancestry controls
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