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GWAS Study

Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.

Yang Q, Köttgen A, Dehghan A et al.

20884846 PubMed ID
GWAS Study Type
50337 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

YQ
Yang Q
KA
Köttgen A
DA
Dehghan A
SA
Smith AV
GN
Glazer NL
CM
Chen MH
CD
Chasman DI
AT
Aspelund T
EG
Eiriksdottir G
HT
Harris TB
LL
Launer L
NM
Nalls M
HD
Hernandez D
AD
Arking DE
BE
Boerwinkle E
GM
Grove ML
LM
Li M
LK
Linda Kao WH
CM
Chonchol M
HT
Haritunians T
LG
Li G
LT
Lumley T
PB
Psaty BM
SM
Shlipak M
HS
Hwang SJ
LM
Larson MG
OC
O'Donnell CJ
UA
Upadhyay A
VD
van Duijn CM
HA
Hofman A
RF
Rivadeneira F
SB
Stricker B
UA
Uitterlinden AG
PG
Paré G
PA
Parker AN
RP
Ridker PM
SD
Siscovick DS
GV
Gudnason V
WJ
Witteman JC
FC
Fox CS
CJ
Coresh J
Chapter II

Abstract

Summary of the research findings

Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD).

28,283 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

50337
Total Participants
GWAS
Study Type
Yes
Replicated
22,054 European ancestry individuals
Replication Participants
European
Ancestry
U.S., Netherlands
Recruitment Country
Chapter IV

AI-Generated Summary

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