Genome-wide association study of prostate cancer mortality.
Penney KL, Pyne S, Schumacher FR et al.
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Abstract
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A pressing clinical issue in prostate cancer is to distinguish which men will have an indolent or aggressive course of disease. Clinical variables such as Gleason grade and stage are useful predictors of lethal cancer; however, the low predictive values of the common Gleason scores, changes in grading over time, and earlier diagnosis of patients due to screening limits their clinical utility. Identifying genetic variants associated with lethal prostate cancer could inform clinical decision making.
196 European ancestry lethal cases, 368 European ancestry long-term survivor cases
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