Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region.
Jordahl KM, Shcherbina A, Kim AE et al.
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Abstract
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Currently known associations between common genetic variants and colorectal cancer explain less than half of its heritability of 25%. As alcohol consumption has a J-shape association with colorectal cancer risk, nondrinking and heavy drinking are both risk factors for colorectal cancer.
4,141 European ancestry heavy drinker cases, 13,979 European ancestry light-to-moderate drinker cases, 13,754 European ancestry nondrinker cases, 5,021 European ancestry heavy drinker controls, 21,658 European ancestry light-to-moderate drinker controls, 15,546 European ancestry nondrinker controls
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