Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.
Traglia M, Girelli D, Biino G et al.
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Abstract
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Hepcidin is the main regulator of iron homeostasis: inappropriate production of hepcidin results in iron overload or iron deficiency and anaemia.
1,657 Val Borbera (founder/genetic isolate) individuals
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