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GWAS Study

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.

Murabito JM, White CC, Kavousi M et al.

22199011 PubMed ID
GWAS Study Type
58409 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MJ
Murabito JM
WC
White CC
KM
Kavousi M
SY
Sun YV
FM
Feitosa MF
NV
Nambi V
LC
Lamina C
SA
Schillert A
CS
Coassin S
BJ
Bis JC
BL
Broer L
CD
Crawford DC
FN
Franceschini N
FR
Frikke-Schmidt R
HM
Haun M
HS
Holewijn S
HJ
Huffman JE
HS
Hwang SJ
KS
Kiechl S
KB
Kollerits B
MM
Montasser ME
NI
Nolte IM
RM
Rudock ME
SA
Senft A
TA
Teumer A
VD
van der Harst P
VV
Vitart V
WL
Waite LL
WA
Wood AR
WC
Wassel CL
AD
Absher DM
AM
Allison MA
AN
Amin N
AA
Arnold A
AF
Asselbergs FW
AY
Aulchenko Y
BS
Bandinelli S
BM
Barbalic M
BM
Boban M
BK
Brown-Gentry K
CD
Couper DJ
CM
Criqui MH
DA
Dehghan A
DH
den Heijer M
DB
Dieplinger B
DJ
Ding J
DM
Dörr M
EC
Espinola-Klein C
FS
Felix SB
FL
Ferrucci L
FA
Folsom AR
FG
Fraedrich G
GQ
Gibson Q
GR
Goodloe R
GG
Gunjaca G
HM
Haltmayer M
HG
Heiss G
HA
Hofman A
KA
Kieback A
KL
Kiemeney LA
KI
Kolcic I
KI
Kullo IJ
KS
Kritchevsky SB
LK
Lackner KJ
LX
Li X
LW
Lieb W
LK
Lohman K
MC
Meisinger C
MD
Melzer D
ME
Mohler ER
MI
Mudnic I
MT
Mueller T
NG
Navis G
OF
Oberhollenzer F
OJ
Olin JW
OJ
O'Connell J
OC
O'Donnell CJ
PW
Palmas W
PB
Penninx BW
PA
Petersmann A
PO
Polasek O
PB
Psaty BM
RB
Rantner B
RK
Rice K
RF
Rivadeneira F
RJ
Rotter JI
SA
Seldenrijk A
SM
Stadler M
SM
Summerer M
TT
Tanaka T
TA
Tybjaerg-Hansen A
UA
Uitterlinden AG
VG
van Gilst WH
VS
Vermeulen SH
WS
Wild SH
WP
Wild PS
WJ
Willeit J
ZT
Zeller T
ZT
Zemunik T
ZL
Zgaga L
AT
Assimes TL
BS
Blankenberg S
BE
Boerwinkle E
CH
Campbell H
CJ
Cooke JP
DG
de Graaf J
HD
Herrington D
KS
Kardia SL
MB
Mitchell BD
MA
Murray A
MT
Münzel T
NA
Newman AB
OB
Oostra BA
RI
Rudan I
SA
Shuldiner AR
SH
Snieder H
VD
van Duijn CM
VU
Völker U
WA
Wright AF
WH
Wichmann HE
WJ
Wilson JF
WJ
Witteman JC
LY
Liu Y
HC
Hayward C
BI
Borecki IB
ZA
Ziegler A
NK
North KE
CL
Cupples LA
KF
Kronenberg F
Chapter II

Abstract

Summary of the research findings

Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts.

38,376 European ancestry individuals, 2,133 Erasmus Rucphen individuals, 1,183 Old Order Amish individuals

Chapter III

Study Statistics

Key metrics and study information

58409
Total Participants
GWAS
Study Type
Yes
Replicated
16,717 European ancestry individuals
Replication Participants
European
Ancestry
U.S., Italy, Netherlands, Austria, Denmark, Germany, U.K., Croatia
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.