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GWAS Study

A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.

Png E, Alisjahbana B, Sahiratmadja E et al.

22239941 PubMed ID
GWAS Study Type
4979 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

PE
Png E
AB
Alisjahbana B
SE
Sahiratmadja E
MS
Marzuki S
NR
Nelwan R
BY
Balabanova Y
NV
Nikolayevskyy V
DF
Drobniewski F
NS
Nejentsev S
AI
Adnan I
VD
van de Vosse E
HM
Hibberd ML
VC
van Crevel R
OT
Ottenhoff TH
SM
Seielstad M
Chapter II

Abstract

Summary of the research findings

There is reason to expect strong genetic influences on the risk of developing active pulmonary tuberculosis (TB) among latently infected individuals. Many of the genome wide linkage and association studies (GWAS) to date have been conducted on African populations. In order to identify additional targets in genetically dissimilar populations, and to enhance our understanding of this disease, we performed a multi-stage GWAS in a Southeast Asian cohort from Indonesia.

108 Indonesian ancestry cases, 115 Indonesian ancestry controls

Chapter III

Study Statistics

Key metrics and study information

4979
Total Participants
GWAS
Study Type
Yes
Replicated
600 Indonesian ancestry cases, 540 Indonesian ancestry controls, 1,837 European ancestry cases, 1,779 European ancestry controls
Replication Participants
South East Asian, European
Ancestry
Indonesia, Russian Federation
Recruitment Country
Chapter IV

AI-Generated Summary

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