HLA class II locus and susceptibility to podoconiosis.
Tekola Ayele F, Adeyemo A, Finan C et al.
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Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived from volcanic rock. The World Health Organization recently designated it as a neglected tropical disease. Podoconiosis develops in only a subgroup of exposed people, and studies have shown familial clustering with high heritability (63%).
194 African ancestry cases, 203 African ancestry controls
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