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GWAS Study

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

Baldwin RM, Owzar K, Zembutsu H et al.

22843789 PubMed ID
GWAS Study Type
1126 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BR
Baldwin RM
OK
Owzar K
ZH
Zembutsu H
CA
Chhibber A
KM
Kubo M
JC
Jiang C
WD
Watson D
ER
Eclov RJ
MJ
Mefford J
MH
McLeod HL
FP
Friedman PN
HC
Hudis CA
WE
Winer EP
JE
Jorgenson EM
WJ
Witte JS
SL
Shulman LN
NY
Nakamura Y
RM
Ratain MJ
KD
Kroetz DL
Chapter II

Abstract

Summary of the research findings

Purpose: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity.

855 European ancestry breast cancer cases

Chapter III

Study Statistics

Key metrics and study information

1126
Total Participants
GWAS
Study Type
Yes
Replicated
154 European ancestry breast cancer cases, 117 African American breast cancer cases
Replication Participants
African American or Afro-Caribbean, European
Ancestry
Chapter IV

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