Menu
GWAS Study

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

Butler AM, Yin X, Evans DS et al.

23139255 PubMed ID
GWAS Study Type
13415 Participants
Scroll to explore
Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BA
Butler AM
YX
Yin X
ED
Evans DS
NM
Nalls MA
SE
Smith EN
TT
Tanaka T
LG
Li G
BS
Buxbaum SG
WE
Whitsel EA
AA
Alonso A
AD
Arking DE
BE
Benjamin EJ
BG
Berenson GS
BJ
Bis JC
CW
Chen W
DR
Deo R
EP
Ellinor PT
HS
Heckbert SR
HG
Heiss G
HW
Hsueh WC
KB
Keating BJ
KK
Kerr KF
LY
Li Y
LM
Limacher MC
LY
Liu Y
LS
Lubitz SA
MK
Marciante KD
MR
Mehra R
MY
Meng YA
NA
Newman AB
NC
Newton-Cheh C
NK
North KE
PC
Palmer CD
PB
Psaty BM
QP
Quibrera PM
RS
Redline S
RA
Reiner AP
RJ
Rotter JI
SR
Schnabel RB
SN
Schork NJ
SA
Singleton AB
SJ
Smith JG
SE
Soliman EZ
SS
Srinivasan SR
ZZ
Zhang ZM
ZA
Zonderman AB
FL
Ferrucci L
MS
Murray SS
EM
Evans MK
SN
Sotoodehnia N
MJ
Magnani JW
AC
Avery CL
Chapter II

Abstract

Summary of the research findings

The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci associated with PR in African Americans.

13,415 African American individuals

Chapter III

Study Statistics

Key metrics and study information

13415
Total Participants
GWAS
Study Type
No
Replicated
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.