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GWAS Study

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

Butler AM, Yin X, Evans DS et al.

23139255 PubMed ID
GWAS Study Type
13415 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BA
Butler AM
YX
Yin X
ED
Evans DS
NM
Nalls MA
SE
Smith EN
TT
Tanaka T
LG
Li G
BS
Buxbaum SG
WE
Whitsel EA
AA
Alonso A
AD
Arking DE
BE
Benjamin EJ
BG
Berenson GS
BJ
Bis JC
CW
Chen W
DR
Deo R
EP
Ellinor PT
HS
Heckbert SR
HG
Heiss G
HW
Hsueh WC
KB
Keating BJ
KK
Kerr KF
LY
Li Y
LM
Limacher MC
LY
Liu Y
LS
Lubitz SA
MK
Marciante KD
MR
Mehra R
MY
Meng YA
NA
Newman AB
NC
Newton-Cheh C
NK
North KE
PC
Palmer CD
PB
Psaty BM
QP
Quibrera PM
RS
Redline S
RA
Reiner AP
RJ
Rotter JI
SR
Schnabel RB
SN
Schork NJ
SA
Singleton AB
SJ
Smith JG
SE
Soliman EZ
SS
Srinivasan SR
ZZ
Zhang ZM
ZA
Zonderman AB
FL
Ferrucci L
MS
Murray SS
EM
Evans MK
SN
Sotoodehnia N
MJ
Magnani JW
AC
Avery CL
Chapter II

Abstract

Summary of the research findings

The PR interval, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricular nodal depolarization. Substantial evidence exists for a genetic contribution to PR, including genome-wide association studies that have identified common genetic variants at 9 loci influencing PR in populations of European and Asian descent. However, few studies have examined loci associated with PR in African Americans.

13,415 African American individuals

Chapter III

Study Statistics

Key metrics and study information

13415
Total Participants
GWAS
Study Type
No
Replicated
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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