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GWAS Study

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

Xu H, Yang W, Perez-Andreu V et al.

23512250 PubMed ID
GWAS Study Type
10284 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

XH
Xu H
YW
Yang W
PV
Perez-Andreu V
DM
Devidas M
FY
Fan Y
CC
Cheng C
PD
Pei D
SP
Scheet P
BE
Burchard EG
EC
Eng C
HS
Huntsman S
TD
Torgerson DG
DM
Dean M
WN
Winick NJ
MP
Martin PL
CB
Camitta BM
BW
Bowman WP
WC
Willman CL
CW
Carroll WL
MC
Mullighan CG
BD
Bhojwani D
HS
Hunger SP
PC
Pui CH
EW
Evans WE
RM
Relling MV
LM
Loh ML
YJ
Yang JJ
Chapter II

Abstract

Summary of the research findings

Acute lymphoblastic leukemia (ALL) is the most common cancer in children and the incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined.

972 European ancestry cases, 1,386 European ancestry controls, 89 African American cases, 1,363 African American controls, 305 Hispanic cases, 1,008 Hispanic controls

Chapter III

Study Statistics

Key metrics and study information

10284
Total Participants
GWAS
Study Type
Yes
Replicated
574 European ancestry cases, 2,601 European ancestry controls, 128 African American cases, 1,075 African American controls, 143 Hispanic cases, 640 Hispanic controls
Replication Participants
European, Hispanic or Latin American, African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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