Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
Sherva R, Tripodis Y, Bennett DA et al.
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Abstract
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Substantial interindividual variability exists in the disease trajectories of Alzheimer's disease (AD) patients. Some decline rapidly whereas others decline slowly, and there are no known explanations for this variability. We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition.
303 European ancestry cases
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