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GWAS Study

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.

Larsen MH, Albrechtsen A, Thørner LW et al.

23823136 PubMed ID
GWAS Study Type
716 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

LM
Larsen MH
AA
Albrechtsen A
TL
Thørner LW
WT
Werge T
HT
Hansen T
GU
Gether U
HE
Haastrup E
UH
Ullum H
Chapter II

Abstract

Summary of the research findings

Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflammatory diseases. This study aimed to find genetic variants that might affect the levels of LPS-induced interleukin (IL)-6, IL-8, IL-10, IL-1ra and tumor necrosis factor (TNF)-α cytokine production.

130 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

716
Total Participants
GWAS
Study Type
Yes
Replicated
586 European ancestry individuals
Replication Participants
European
Ancestry
Denmark
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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