Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
Ji Y, Schaid DJ, Desta Z et al.
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Abstract
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Aims: Citalopram (CT) and escitalopram (S-CT) are among the most widely prescribed selective serotonin reuptake inhibitors used to treat major depressive disorder (MDD). We applied a genome-wide association study to identify genetic factors that contribute to variation in plasma concentrations of CT or S-CT and their metabolites in MDD patients treated with CT or S-CT.
300 European ancestry Escitalpram treated individuals, 130 European ancestry Citalopram treated individuals
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