Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.
Chung WH, Chang WC, Lee YS et al.
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Abstract
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Importance: The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown.
60 Han Chinese ancestry cases, 412 Han Chinese ancestry controls
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