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GWAS Study

Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.

Mtatiro SN, Singh T, Rooks H et al.

25372704 PubMed ID
GWAS Study Type
1534 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MS
Mtatiro SN
ST
Singh T
RH
Rooks H
MJ
Mgaya J
MH
Mariki H
SD
Soka D
MB
Mmbando B
ME
Msaki E
KI
Kolder I
TS
Thein SL
MS
Menzel S
CS
Cox SE
MJ
Makani J
BJ
Barrett JC
Chapter II

Abstract

Summary of the research findings

Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be affected by variants at three loci on chromosomes 2, 6 and 11, but it is likely that additional loci remain to be discovered.

1,213 Tanzanian ancestry cases

Chapter III

Study Statistics

Key metrics and study information

1534
Total Participants
GWAS
Study Type
Yes
Replicated
321 Afro-Caribbean and Sub-Saharan African cases
Replication Participants
Sub-Saharan African, Sub-Saharan African, African American or Afro-Caribbean
Ancestry
United Republic of Tanzania, U.K.
Recruitment Country
Chapter IV

AI-Generated Summary

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Independent AI summary of health and genetic findings from the published study

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