New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
up to 56,910 European ancestry men, up to 86,570 European ancestry women
Study Statistics
Key metrics and study information
Analysis
Comprehensive review of health and genetic findings
Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.
Analysis In Progress
Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Scientific Assessment
Related Publications
Other publications that may be of interest
The DNA virome varies with human genes and environments.
Kamitaki N
Nature
Torque teno virus 16 (TUS01) DNA load in blood
Host control of persistent Epstein-Barr virus infection.
Schmidt A
Nature
EBV read positivity (EBV-read count 1-18)
Human and bacterial genetic variation shape oral microbiomes and health.
Kamitaki N
Nature
Relative abundance of genus Peptostreptococcaceae unclassified in oral microbiome
Insights into DNA repeat expansions among 900,000 biobank participants.
Hujoel MLA
Nature
Somatic instability of CAG repeats at TCF4
A cross-population compendium of gene-environment interactions.
Namba S
Nature
Total bilirubin x ever-smoking interaction
Explore More Research
Discover the latest findings in health and genetic research