Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
de Moor MH, van den Berg SM, Verweij KJ et al.
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Abstract
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Importance: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63,000 participants (including MDD cases).
Up to 627 Cilento (founder/genetic isolate) individuals, up to 2,296 Erasmus Rucphen (founder/genetic isolate) individuals, up to 1,650 Orcadian (founder/genetic isolate) individuals, up to 909 Vis (founder/genetic isolate) individuals, up to 58,179 European ancestry individuals
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