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GWAS Study

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

Tosto G, Fu H, Vardarajan BN et al.

26339675 PubMed ID
GWAS Study Type
5300 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

TG
Tosto G
FH
Fu H
VB
Vardarajan BN
LJ
Lee JH
CR
Cheng R
RD
Reyes-Dumeyer D
LR
Lantigua R
MM
Medrano M
JI
Jimenez-Velazquez IZ
EM
Elkind MS
WC
Wright CB
SR
Sacco RL
PM
Pericak-Vance M
FL
Farrer L
RE
Rogaeva E
SG
St George-Hyslop P
RC
Reitz C
MR
Mayeux R
Chapter II

Abstract

Summary of the research findings

Objective: In the context of late-onset Alzheimer's disease (LOAD) over 20 genes have been identified but, aside APOE, all show small effect sizes, leaving a large part of the genetic component unexplained. Admixed populations, such as Caribbean Hispanics, can provide a valuable contribution because of their unique genetic profile and higher incidence of the disease. We aimed to identify novel loci associated with LOAD.

2,451 Caribbean Hispanic cases, 2,063 Caribbean Hispanic controls

Chapter III

Study Statistics

Key metrics and study information

5300
Total Participants
GWAS
Study Type
Yes
Replicated
550 Caribbean Hispanic cases, 236 Caribbean Hispanic controls
Replication Participants
Hispanic or Latin American
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.