Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies.
Allen NB, Lloyd-Jones D, Hwang SJ et al.
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Abstract
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Multiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however, little is known about gene variants associated with ideal CV health. Our objective was to carry out a genome-wide association study on the trait.
883 European ancestry individuals with clinical and behavioral ideal cardiovascular health, 10,825 European ancestry individuals without clinical and behavioral ideal cardiovascular health
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