Association of 3q13.32 variants with hip trochanter and intertrochanter bone mineral density identified by a genome-wide association study.
Pei YF, Xie ZG, Wang XY et al.
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Abstract
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We performed a GWAS of trochanter and intertrochanter bone mineral density (BMD) in the Framingham Heart Study and replicated in three independent studies. Our results identified one novel locus around the associated variations at chromosomal region 3q13.32 and replicated two loci at chromosomal regions 3p21 and 8q24. Our findings provide useful insights that enhance our understanding of bone development, osteoporosis, and fracture pathogenesis.
6,912 European ancestry individuals
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