Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia.
Charles BA, Hsieh MM, Adeyemo AA et al.
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Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen Receptor for Chemokines (DARC) gene, specifically DARC null red cell phenotype, was associated with BEN. However, the mechanism of this red cell phenotype leading to low white cell count remained elusive.
783 African American individuals with low white blood cell count, 1,214 African American individuals with high white blood cell count
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